酒精性急性胰腺炎的动物模型研究进展
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1.甘肃中医药大学 中医临床学院,甘肃 兰州730000;2.甘肃省中医院 2. 脾胃病科 3. 甘肃省中医院 脑病三科,甘肃 兰州730050

作者简介:

李美娜,甘肃中医药大学中医临床学院硕士研究生,主要从事消化系统疾病中医诊治方面的研究。

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Advances in research of animal models of alcoholic acute pancreatitis
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Affiliation:

1.Clinical College of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China;2.Department of Gastroenterology 3. The Third Department of Neurology, Gansu Provincial Hospital of TCM, Lanzhou 730050, China

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    摘要:

    酒精性急性胰腺炎(AAP)是目前仅次于胆源性急性胰腺炎(ABP)最严重的急性胰腺炎(AP)类型,其病情更重、病死率更高,多器官损害更明显。有研究表明,酒精使发生重症急性胰腺炎(SAP)的危险度增加,AAP较ABP易发展成SAP。近年来AAP相关研究正成为热点,获得理想动物模型有助于深入研究AAP的发病机制,而目前针对AAP研究构建有效的动物模型方法却十分欠缺。故笔者就国内外AAP动物模型研究方法进行综述,以期为AAP研究提供新思路。

    Abstract:

    Alcoholic acute pancreatitis (AAP) is currently the second most severe type of acute pancreatitis (AP) following acute biliary pancreatitis (ABP), with a more serious illness, higher mortality rate, and more severe multiple organ damage. Studies have shown that alcohol increases the risk of development of severe acute pancreatitis (SAP), and AAP is more likely to develop into SAP than ABP. In recent years, AAP-related research has become a hot topic, and obtaining ideal animal models can help in-depth research on the pathogenesis of AAP. However, there is a lack of effective methods for AAP animal model construction at present. Therefore, the authors review the common methods for AAP animal models at home and abroad, so as to provide new ideas for AAP research.

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李美娜,李生财,常调芳,胡宗轩,张旭彤.酒精性急性胰腺炎的动物模型研究进展[J].中国普通外科杂志,2023,32(3):448-453.
DOI:10.7659/j. issn.1005-6947.2023.03.015

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  • 收稿日期:2022-04-26
  • 最后修改日期:2022-08-31
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  • 在线发布日期: 2023-03-30