主动脉弓腔内修复术后卒中的防治研究进展
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中国人民解放军总医院第一医学中心 血管外科,北京 100853

作者简介:

郭伟,中国人民解放军总医院第一医学中心主任医师,主要从事主动脉及外周动脉的诊断及治疗方面的研究。

基金项目:

国家重点研发计划基金资助项目(2020YFC1107701)。


Research progress in the prevention and treatment of stroke after endovascular aortic arch repair
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Affiliation:

Department of Vascular Surgery, the First Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China

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    摘要:

    传统开放性主动脉弓修复手术存在较高的围术期并发症和死亡风险。主动脉弓腔内修复术(EAAR)为开放手术高风险患者提供了微创治疗选择。然而,与传统开放手术相比,EAAR仍具有较高的卒中风险。分支技术是腔内治疗主动脉弓部疾病最具应用前景的技术之一,尽管其早期卒中风险略高于传统开放手术,但对于高风险患者来说,这样的风险是可以接受的。导致术后卒中的主要原因包括固体栓塞、气体栓塞和脑灌注不足。术前评估、围术期监测、药物预防和优化术中操作是预防EAAR术后卒中发生的关键策略。对于已经发生卒中的患者,及时诊断和评估、药物治疗和必要的手术干预是治疗的基石,而多学科有效协作对于改善患者的病情和预后亦尤为重要。目前,EAAR术后卒中的防治仍有很大的研究空间,因此,笔者就EAAR术后早期卒中的发生率、发生机制、危险因素以及预防和治疗策略方面进行论述,以期为临床工作提供思路。

    Abstract:

    Conventional open repair of the aortic arch is associated with a higher risk of perioperative complications and mortality. Endovascular aortic arch repair (EAAR) offers a minimally invasive treatment option for patients deemed high risk for open surgery. However, compared to conventional open surgery, EAAR still carries an elevated risk of stroke. Branch TEVAR represent one of the most promising techniques for the endovascular treatment of aortic arch diseases. Although the early stroke risk is slightly higher than that of conventional open surgery, such risks are considered acceptable for high-risk patients. The primary causes of postoperative stroke include solid embolism, gas embolism, and cerebral hypoperfusion. Key strategies for preventing stroke following EAAR include preoperative assessment, perioperative monitoring, pharmacological prevention, and optimization of intraoperative procedures. For patients who have already developed a stroke, prompt diagnosis and assessment, pharmacological treatment, and appropriate surgical interventions form the cornerstone of treatment, and effective multidisciplinary collaboration is particularly crucial for improving the patient's condition and prognosis. Currently, there is still considerable research space in the prevention and treatment of stroke associated with EAAR. Therefore, the authors address the incidence, mechanisms, risk factors, as well as prevention and treatment strategies for early postoperative stroke following EAAR, to provide insights for clinical work.

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高江平,郭伟.主动脉弓腔内修复术后卒中的防治研究进展[J].中国普通外科杂志,2023,32(12):1819-1828.
DOI:10.7659/j. issn.1005-6947.2023.12.001

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  • 收稿日期:2023-10-09
  • 最后修改日期:2023-12-07
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  • 在线发布日期: 2024-01-09