Hepatolithiasis is a common disease in the central and western regions of our country, especially prevalent in Hunan province. This disease poses significant challenges in diagnosis and treatment, severely impacting public health. Due to the complex and variable nature of the disease, there are numerous and diverse treatment methods, often with unsatisfactory results, leading patients into a vicious cycle of surgery, postoperative stone residue or recurrence, reoperation, stone residue or recurrence again, ultimately resulting in life-threatening complications such as biliary cirrhosis and bile duct cancer. Therefore, it is extremely necessary to standardize the diagnosis and treatment of hepatolithiasis. The Hepatobiliary Surgery Professional Committee of Hunan Medical Association, the Professional Committee of Enhanced Recovery After Surgery of Hunan Health Management Association, the Hepatobiliary Surgery Professional Committee of Hunan International Medical Exchange and Promotion Association, and the Hunan Alliance of Hepatobiliary and Pancreatic Surgery have organized discussions among experts in hepatobiliary surgery in the province to draft the Hunan expert consensus on comprehensive diagnosis and treatment of hepatolithiasis, aiming to provide guidance and basis for the standardized diagnosis and treatment of hepatolithiasis.