Breast cancer is the most common malignancy among women worldwide and significantly impacts patients' quality of life. With advancements in medical technology, treatment strategies for breast cancer are increasingly shifting toward precision and minimally invasive approaches. High-intensity focused ultrasound (HIFU), characterized by its non-invasive and non-ionizing nature, has been widely applied in the treatment of various benign and malignant tumors. HIFU holds great potential in breast cancer therapy, demonstrating significant antitumor effects in thermal ablation, chemotherapy, immunotherapy, and targeted therapy combinations. HIFU not only ablates tumor tissue and activates antitumor immune responses, but also, when combined with drugs, enhances therapeutic efficacy, promotes drug accumulation in tumor tissues, reduces side effects, and improves long-term outcomes. This article reviews the application of HIFU in the treatment of breast cancer, providing a reference for clinical practice and research.