多中心近10年(2013—2022年)161例破裂腹主动脉瘤临床分析
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1.南京大学医学院附属鼓楼医院 血管外科,江苏 南京 210008;2.安徽医科大学第一附属医院 血管外科,安徽 合肥 230001;3.江苏省昆山市中医医院 血管外科,江苏 昆山215300;4.南昌大学第二附属医院 血管外科,江西 南昌 330000;5.山东大学齐鲁医院 心血管外科,山东 济南 250012

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陈可,南京大学医学院附属鼓楼医院博士研究生,主要从事深静脉血栓以及主动脉相关疾病基础与临床方面的研究

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Clinical analysis of 161 multicenter cases of ruptured abdominal aortic aneurysms over the past decade (2013—2022)
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1.Department of Vascular Surgery, Drum Tower Hospital Affiliated to the Medical School, Nanjing University, Nanjing210008, China;2.Department of Vascular Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei230001, China;3.Department of Vascular Surgery, Kunshan Hospital of Traditional Chinese Medicine, Kunshan, Jiangsu215300, China;4.Department of Vascular Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang330000, China;5.Department of Cardiovascular Surgery, Qilu Hospital, Shandong University, Ji'nan250012, China

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    摘要:

    背景与目的 破裂是腹主动脉瘤最严重的并发症,由于需要快速诊断、紧急手术,且手术难度极大,病死率一直居高不下。目前,国内针对破裂腹主动脉瘤(rAAA)的报道极少,给rAAA的防治带来了诸多困难。本研究收集了多中心、大样本量rAAA患者的流行病学特征、治疗效果及预后资料,分析近10年国内rAAA手术的现状与趋势,以期为临床提供参考。方法 回顾性分析2013年1月—2022年12月五家大型血管外科中心收治的161例rAAA病例(南京大学医学院附属鼓楼医院50例、安徽医科大学第一附属医院19例、南昌大学第二附属医院33例、山东大学齐鲁医院31例、中国科学技术大学附属第一医院28例)的临床与随访资料。结果 161例患者中,男性124例(77.02%),女性37例(22.98%);平均年龄68.27岁;男性与女性的中位发病年龄分别为70岁与71岁。全组平均动脉瘤直径为7.11 cm,其中男性为7.72 cm、女性为6.82 cm,差异有统计学意义(P<0.05)。患者的主要合并症为高血压、冠心病。超过80%的患者首发症状为腹痛,以腰背部疼痛为首发症状的患者占比为15%,有8例患者因头晕、视物模糊等症状就诊。161例患者中,行传统开放手术(OSR组)86例,行主动脉瘤腔内修复术(EVAR组)75例,EVAR占比在逐年增加,近5年接近70%,且70岁以上患者中高达90%。所有OSR组均采用全身麻醉,而EVAR组20例采用局部麻醉,55例采用全身麻醉。此外,OSR组与EVAR组患者在手术时间(231.77 min vs. 162.49 min)、术中输血量(1 578.56 mL vs. 843.87 mL)、住院时间(21.21 d vs. 15.34 d)、ICU住院时间(8.28 d vs. 5.49 d)、住院费用(10.85万元 vs. 13.28万元)方面差异均有统计学意义(均P<0.05)。EVAR组与OSR组在总并发症及围术期死亡发生率方面差异无统计学意义(均P>0.05),患者围术期死亡原因主要包括呼吸循环衰竭、急性心肌梗死、严重感染等。92例患者术后获得有效随访,随访时间10~142个月,生存分析结果显示,OSR组与EVAR组患者生存率差异无统计学意义(P=0.318 2)。结论 rAAA是一种少见的高风险疾病,男性与女性患者的临床特点存在一定差异;EVAR手术量呈现快速上升的趋势,但EVAR在改善长期生存率方面较OSR无明显优势。

    Abstract:

    Background and Aims Rupture is the most serious complication of abdominal aortic aneurysm, requiring rapid diagnosis, emergency surgery, and posing significant surgical challenges, with high mortality rates. Currently, there is very limited reporting on ruptured abdominal aortic aneurysm (rAAA) in our country, which presents numerous difficulties for the prevention and treatment of rAAA. This study collected the data of epidemiological characteristics, treatment outcomes, and prognosis of rAAA patients from multiple centers with a large sample size, analyzing the current status and trends of rAAA surgery in China over the past decade, aiming to provide reference for clinical practice.Methods The clinical and follow-up data of 161 rAAA patients treated at five major vascular surgery centers (50 from Drum Tower Hospital Affiliated to the Medical School, Nanjing University; 19 from the First Affiliated Hospital of Anhui Medical University; 33 from the Second Affiliated Hospital of Nanchang University; 31 from Qilu Hospital, Shandong University; and 28 from the First Affiliated Hospital of the University of Science and Technology of China) were retrospectively analyzed.Results Among the 161 patients, 124 (77.02%) were male and 37 (22.98%) were female, with an average age of 68.27 years. The median age at diagnosis was 70 years for males and 71 years for females. The overall mean aneurysm diameter was 7.11 cm, with males at 7.72 cm and females at 6.82 cm, showing a statistically significant difference (P<0.05). The main comorbidities were hypertension and coronary artery disease. Over 80% of patients presented with abdominal pain as the initial symptom, while 15% presented with low back pain, and 8 patients sought medical attention for dizziness or visual disturbances. Among the 161 patients, 86 underwent open surgical repair (OSR), and 75 received endovascular aneurysm repair (EVAR). The proportion of EVAR has increased annually, reaching nearly 70% in the past five years, and up to 90% in patients aged over 70 years. All OSR procedures were performed under general anesthesia, while 20 EVAR cases used local anesthesia and 55 used general anesthesia. Compared to the OSR group, the EVAR group showed significant differences in operative time (231.77 min vs. 162.49 min), intraoperative blood transfusion volume (1 578.56 mL vs. 843.87 mL), length of hospital stay (21.21 d vs. 15.34 d), ICU stay duration (8.28 d vs. 5.49 d), and hospitalization costs (108 500 CNY vs. 132 800 CNY) (all P<0.05). No significant differences were found between the EVAR and OSR groups in total complications or perioperative mortality rates (both P>0.05). The main causes of perioperative death included respiratory and circulatory failure, acute myocardial infarction, and severe infections. Postoperative follow-up was effectively conducted for 92 patients, with follow-up durations ranging from 10 to 142 months. Survival analysis revealed no significant difference in survival rate between the OSR and EVAR groups (P=0.318 2).Conclusion rAAA is a rare and high-risk disease, with certain clinical differences between male and female patients. The number of EVAR procedures has increased rapidly; however, EVAR has not shown a significant advantage over OSR in improving long-term survival rates.

    图1 2013—2022年多中心rAAA手术方式的演变Fig.1 Evolution of multi-center rAAA surgical methods from 2013 to 2022
    图2 EVAR组与OSR组患者术后生存情况比较Fig.2 Comparison of postoperative survival between EVAR and OSR groups
    表 1 男性与女性rAAA患者的基本特征比较Table 1 Comparison of basic characteristics between male and female rAAA patients
    表 2 两组rAAA患者手术情况的比较Table 2 Comparison of surgical conditions between the two groups of rAAA patients
    表 3 EVAR组与OSR组患者术后并发症与围术期死亡情况[n(%)]Table 3 Postoperative complications and perioperative mortality in EVAR and OSR groups [n(%)]
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陈可,查斌山,曾家琪,赵文鹏,杨志浩,刘昭,周敏,乔彤,赵鑫,周为民,陈智勇,李文东,李晓强.多中心近10年(2013—2022年)161例破裂腹主动脉瘤临床分析[J].中国普通外科杂志,2024,33(12):1967-1974.
DOI:10.7659/j. issn.1005-6947.2024.12.004

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  • 收稿日期:2024-08-11
  • 最后修改日期:2024-12-16
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  • 在线发布日期: 2025-01-14