Background and Aims Reconstructing huge abdominal wall defects after abdominal wall tumor resection is a significant challenge for surgeons. Here, we summarize the experience of our team in repairing these defects using an anterolateral thigh chimeric perforator flap combined with artificial materials, within a multidisciplinary collaborative framework, aiming to provide a reference for other practitioners.Methods The clinicopathologic data of 7 patients who underwent primary reconstruction of large abdominal wall defects after malignant tumor resection, using an anterolateral thigh chimeric perforator flap combined with artificial materials, at Xiangya Hospital, Central South University, between October 2019 and April 2024, were retrospectively analyzed. The clinical outcomes were evaluated.Results All 7 patients successfully underwent both tumor resection and primary abdominal wall reconstruction without surgery-related mortality. The wound in all patients healed in one stage, with no severe complications such as surgical site infections or flap necrosis. During a follow-up period of 6 to 54 months, 2 patients experienced tumor recurrence, one of whom died (exact cause unknown), while the other continued anti-tumor treatment. The remaining 5 patients were alive without recurrence. One patient developed abdominal wall bulging, but no obvious incisional hernia occurred in any of the patients.Conclusion The use of an anterolateral thigh chimeric perforator flap combined with artificial materials for repairing large abdominal wall defects after abdominal tumor resection can achieve satisfactory therapeutic outcomes. This approach is a feasible and safe method for abdominal wall reconstruction.