肝性骨病诊疗中国专家共识(2026年版)
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国家自然科学基金资助项目(32271187,32300646,32571329);中国科学技术部基金资助项目(2024YFA1107700,2024YFA1107704);江苏省自然科学基金项目青年基金资助项目(BK20230300);新疆维吾尔自治区自然科学基金资助项目(2023D01D05);江苏省卫生健康委医学科研基金资助项目(H2023103);高水平医院科技创新支撑计划应用基础研究基金资助项目(KJCXQ2024012)。


Chinese expert consensus on the diagnosis and management of hepatic osteodystrophy (2026 edition)
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    摘要:

    肝性骨病(HOD)是慢性肝病或肝移植后发生的代谢性骨病,以骨质疏松和(或)骨软化症为主要表现。由于慢性肝病病因复杂,HOD临床表现异质性强,早期诊断困难且易被忽视,目前国际上尚缺乏统一的诊疗指南。中华医学会医学细胞生物学分会、江苏省研究型医院学会、江苏省发育生物学会及江苏省医师协会外科分会组织肝病学、骨科学、影像学、检验医学及基础医学等多学科专家,在系统评价国内外最新研究证据并结合我国临床实践的基础上,围绕HOD流行病学、危险因素、发病机制、筛查与预防、诊断与鉴别诊断、治疗及随访管理等关键问题形成31条专家意见,制定《肝性骨病诊疗中国专家共识(2026年版)》,旨在为HOD规范化筛查、诊断、治疗及长期管理提供参考依据,改善患者临床结局和生活质量。

    Abstract:

    Hepatic osteodystrophy (HOD) is a metabolic bone disorder that occurs in patients with chronic liver disease or following liver transplantation, and is primarily characterized by osteoporosis and/or osteomalacia. Owing to the heterogeneous etiologies of chronic liver diseases, HOD exhibits substantial clinical heterogeneity, making early diagnosis challenging and leading to frequent underrecognition in clinical practice. To date, no universally accepted guideline is available for the diagnosis and management of HOD. The Chinese Medical Association's Medical Cell Biology Branch, Jiangsu Research Hospital Society, Jiangsu Development Biology Society, and Jiangsu Surgical Physicians Association convened a multidisciplinary panel of experts in hepatology, orthopedics, radiology, laboratory medicine, and basic medical sciences. Based on a systematic review of the latest national and international evidence and informed by current clinical practice in China, the panel developed 31 expert recommendations addressing key issues, including the epidemiology, risk factors, pathogenesis, screening and prevention, diagnosis and differential diagnosis, treatment, and follow-up management of HOD, and formulated the Chinese expert consensus on the diagnosis and management of hepatic osteodystrophy (2026 edition). This consensus aims to provide evidence-informed recommendations for the standardized screening, diagnosis, treatment, and long-term management of HOD, thereby improving clinical outcomes and quality of life in affected patients.

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.肝性骨病诊疗中国专家共识(2026年版)[J].中国普通外科杂志,2026,35(7):1269-1286.
DOI:10.7659/j. issn.1005-6947.260182

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  • 收稿日期:2026-03-31
  • 最后修改日期:2026-07-17
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  • 在线发布日期: 2026-08-31
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